|3.What is monobenzone cream and how to work?
Monobenzone, also called Benoquin, iis a depigmenting agent. It works by increasing the amount of skin pigment molecules (melanin) eliminated from skin cells in the body.
Monobenzone is used to permanently depigment (lighten) skin in people with a condition called vitiligo. Depigmenting (lightening) darker skin around areas of skin affected by vitiligo helps even out the coloring and appearance of the skin.
The topical application of monobenzone in animals decreases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.
The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes. Therefore, monobenzone is used as a topical medicine to permanently depigment normal skin surrounding vitiliginous lesions only in patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.